10 edition of Microtubule Targets in Cancer Therapy (Cancer Drug Discovery and Development) found in the catalog.
May 2, 2008
by Humana Press
Written in English
|The Physical Object|
|Number of Pages||690|
FDA granted accelerated approval to Padcev, a Nectindirected antibody and microtubule inhibitor conjugate, meaning the drug specifically targets . Targets of microtubule-binding reagents in cancer therapy The targets of microtubule-binding agents in cancer therapy in-clude both cancer cells and vascular endothelial cells. Microtu-bule-bindingagents,either microtubule-stabilizingagents or mi-crotubule-destabilizing agents, could cause disruption of micro-.
Title: Taxanes: Microtubule and Centrosome Targets, and Cell Cycle Dependent Mechanisms of Action VOLUME: 3 ISSUE: 3 Author(s):M. Abal, J. M. Andreu and I. Barasoain Affiliation:Institut Curie UMR CNRS, 26 rue d'Ulm, Paris Cedex05, France Keywords:taxanes, centrosome targets, paclitaxel, vinca alkaloids, bcl-2 Abstract: Microtubules are highly dynamic cellular polymers made of αβ. Microtubule motor proteins (kinesins) and centosomal proteins known to be involved microtubule functions in mitosis are therefore potential targets for cancer therapy. Eg5 is critical for proper spindle formation during mitosis and it has received the most attention as a target for cancer therapy Cited by:
Abstract: Microtubule-Targeting Agents (MTAs) constitute a class of drugs largely used in cancer treatment. Among them, both taxanes and Vinca-alkaloids are known to inhibit cancer cell proliferation by inducing cell cycle arrest and subsequent by: Introduction. Breast cancer remains the most commonly diagnosed cancer in women, despite substantial progress in its prevention, diagnosis, and treatment cancer usually originates from the inner lining of mammary ducts and lobules and can metastasize to the bone, lung, liver, and brain most cases, the breast-conserving surgery combined with radiation therapy or Cited by:
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Microtubule Targets in Cancer Therapy presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available/5(2).
The tubulin/microtubule system is an important target for anticancer therapy. Two of the most clinically valuable groups of these agents are the vinca alkaloids and taxanes.
In recent years, new tubulin‐binding agents have been under preclinical or clinical by: This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates Microtubule Targets in Cancer Therapy book potential of microtubules in cancer therapy.
The first group is microtubule-destabilizing agents, which inhibit microtubule polymerization at high concentrations and include several compounds such as the Vinca alkaloids (vinblastine, vincristine, vinorelbine, vindesine and vinflunine), cryptophycins, halichondrins, estramustine, colchicine and combretastatins, that are used clinically or are under clinical investigation for treatment of cancer.
Cited by: The tubulin/microtubule system is an important target for anticancer therapy. Two of the most clinically valuable groups of these agents are the vinca alkaloids and taxanes. In recent years, new tubulin-binding agents have been under preclinical or clinical development.
For this reason, microtubule has become a notable target for chemotherapeutic achievements. Microtubule Targeting Agents (MTAs) that nowadays are used in chemotherapy, induce microtubule polymerization or by: 6.
For cancer therapy, microtubule network is an attractive cellular target. Main component of cell cycle is mitotic stage, particularly when the mitotic spindle separates the replicated chromosomes.
The rapid microtubule dynamics also play a critical role for activities of the bipolar spindle. The tubulin/microtubule system is an important target for anticancer therapy. Two of the most clinically valuable groups of these agents are the vinca alkaloids and taxanes.
In recent years, new. For any microtubule-targeting drug to be suitable for cancer treatment, there must be a mechanism to selectively target cancer cells over normal healthy cells of the human body. This could be as simple as targeting rapidly dividing cells of the tumor by disrupting their mitotic spindle.
Abstract. The microtubule-targeting agents have made significant contributions to cancer therapy over the past 50 years. The vinca alkaloids and taxanes have been used to treat a broad range of malignancies, including leukemias and lymphomas and many types of solid by: Abstract.
Drugs that target cellular microtubules are some of the most important agents used in the treatment of adult and pediatric cancers. This chapter aims to provide an overview of diverse microtubule targeting agents, including microtubule stabilizers and destabilizers, and describes how these agents bind to tubulin/microtubules and suppress microtubule dynamics leading to defects in Cited by: 4.
Microtubules represent a highly-validated target in cancer therapy, explaining the abundance of efforts to develop novel agents directed against this target. All of the currently approved compounds bind directly to tubulin, either to soluble tubulin or to tubulin that is polymerized into microtubules, although the binding occurs at different sites on the tubulin molecule or to different regions of the by: such, microtubules are a highly attractive target for anticancer d rug design.
The tubulin-binding agents (TBAs; also refe rred to as anti-microtubule or microtubule-targeted age nts) are amongst the most widely used chemotherapeutic drugs in cancer treatment. Their efficacy has been demon strated in the.
Several targets have been identified for lung cancer therapy, amongst which ‘Microtubule’ and its dynamics are the most widely studied and used in therapy. Tubulin–microtubule polymer dynamics are highly sought after targets in the field of anti-cancer drug : Santanu Paul, Subhendu Chakrabarty, Subhendu Chakrabarty, Suvranil Ghosh, Debasish Nag, Amlan Das, D.
Targeting Microtubules by Natural Agents for Cancer Therapy and non-small cell lung cancer. As a microtubule II together with a number of other targets important in cancer therapy, we.
Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy. Microtubule-targeted drugs, including Cited by: The effectiveness of microtubule-targeting drugs for cancer therapy has been impaired by various side effects, notably neurological and hematological toxicities.
Drug resistance is another notorious factor that thwarts the effectiveness of these agents, as with many other cancer by: Owing to their potent cytotoxicity, tubulin inhibitors have been a mainstay for cancer therapy and are the most validated payloads used for the design of ADC-mediated targeted.
Microtubules are engaged in cellular processes such as transport, cell shape, migration, and mitosis. It is the critical role in mitosis that makes them targets for cancer therapy (Perez, ).
Microtubule inhibitors are divided into two groups: stabilizing and destabilizing agents. Title:Microtubule Targeting Agents: A Benchmark in Cancer Therapy VOLUME: 8 ISSUE: 3 Author(s):Verma Nitika and Khatri Kapil Affiliation:ISF College of Pharmacy, Ferozepur GT Road, Moga, Punjab, India.
Keywords:Apoptosis, cancer, depolymerisation, microtubule targeting agents, stabilization. Abstract:The treatment of many diseases owes much to the important medicines that Cited by: 9. Abstract. The success of drugs that target mitotic spindle microtubules to treat cancer has spurred an interest in identifying other spindle proteins as potential drug targets that may be similarly effective yet have fewer side by: 1.
Microtubules: Important Target for Cancer Therapy. Microtubules play an essential role in several eukaryotic cellular processes such as cell growth and division, motility, intracellular trafficking, and the ability to adapt to a variety of shapes to interact with the environment ().As a result of the great success of the mitotic agents in the treatment of cancer thereby, microtubules represent Cited by: Microtubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma Herbert H Loong, Winnie YeoDepartment of Clinical Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, State Key Laboratory in Oncology in South China, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong KongAbstract: In mammalian cells, microtubules are .